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MEK Inhibitors

CIP-137401 Lead MEK Inhibitor

Design of a new class of MEK inhibitor
  • AlloMek's novel class of MEK inhibitors were designed based on x-ray crystal structure information to improve potential liabilities of MEK compounds currently in the clinic
Allosteric Inhibition
  • Allosteric kinase inhibitors have a unique way of binding to the enzyme. Allosteric kinase inhibitors bind to the enzyme in a site distinct from the "active site". Allosteric kinase inhibitors are not ATP competitive and this leads to a higher level of selectivity vs. other kinases. Allosteric MEK inhibitors have been tested against over 200 kinases and are not active.